Annabelle Parent

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

This study identifies age-dependent neuroinflammatory changes in NM-containing neurons linked to neurodegeneration, with GPNMB as a conserved protective factor in Parkinson's disease.

The paper uses NM-sensitive MRI to study neuromelanin accumulation and neurodegeneration in Parkinson's disease models, finding a biphasic signal change linked to a pathogenic threshold.

This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.

This study investigates how adult-specific Reelin expression affects striatal neuronal organization and its implications for neuropsychiatric disorders using mouse models.

This study reduces age-related neuromelanin accumulation in a humanized rodent model, mitigating Parkinson's disease features by preserving dopamine homeostasis and neuronal integrity.