Stéphane Lehéricy

Saccadic network dysfunction underlies eye-movement variability in early Parkinson's disease

This study identifies increased intra-individual saccadic variability and altered functional connectivity in early Parkinson's disease, showing their potential as biomarkers for early diagnosis.

Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease

Age-trajectories of higher-order diffusion properties of major brain metabolites in cerebral and cerebellar grey matter using in vivo diffusion-weighted MR spectroscopy at 3T

This study examines age-related changes in diffusion properties of brain metabolites in cerebral and cerebellar grey matter using diffusion-weighted MR spectroscopy, finding non-significant trends in diffusivity and kurtosis with age.

Longitudinal neuromelanin changes in prodromal and early Parkinson's disease in humans and rat model

The paper uses NM-sensitive MRI to study neuromelanin accumulation and neurodegeneration in Parkinson's disease models, finding a biphasic signal change linked to a pathogenic threshold.

Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics

This study shows that dural venous stenoses impair lymphatic drainage and brain fluid clearance, and that restoring venous flow can improve clearance in a mouse model.

The role of dopaminergic, cholinergic and noradrenergic networks in hyposmia in Parkinson's disease

This study investigates network alterations in olfactory dysfunction in Parkinson's disease and iRBD patients using multimodal MRI, finding correlations between olfactory function and specific brain regions and networks.

Non-ablative disease-modifying effects of magnetic resonance-guided focused ultrasound in neuromelanin-producing parkinsonian rodents

Transcranial focused ultrasound reduces neuromelanin accumulation and provides therapeutic benefits in parkinsonian rats without additional interventions.

3D-imaging reveals conserved cerebrospinal fluid drainage via meningeal lymphatic vasculature in mice and humans

The paper establishes the 3D anatomy of meningeal lymphatic vasculature and CSF drainage in mice and humans using imaging techniques, showing conserved lymphatic structures.

The R1-weighted connectome: complementing brain networks with a myelin-sensitive measure

The paper introduces an R1-weighted connectome to complement traditional connectomes by incorporating myelin-sensitive MRI data, revealing differences in modular organization and functional gradients.

Rere-dependent Retinoic Acid signaling controls brain asymmetry and handedness

The paper shows that Retinoic Acid signaling, specifically through Rere, controls brain asymmetry and handedness in zebrafish and mouse.

Offline impact of transcranial focused ultrasound on cortical activation in primates

This paper demonstrates that transcranial focused ultrasound induces sustained, reversible neural modulation in primate brains, altering connectivity patterns in targeted regions.

Non-invasive ultrasonic modulation of visual evoked response by GABA delivery through the blood brain barrier

This study shows that non-invasive ultrasound can deliver GABA to the visual cortex of non-human primates, reducing visual evoked activity, with GABA inhibition being more impactful than BBB disruption.