IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2V617F clonal hematopoiesis-driven atherosclerosis.
Mojdeh S. Tavallaie, Cheng-Chieh Hsu, Brian D. Hardaway, Huijuan Dou, Trevor P. Fidler, Eunyoung Kim, Sandra Abramowicz, David Ngai, Tong Xiao, Nan Wang, Marit Westerterp, Alan R. Tall
This study shows that IL-18 inhibition increases atherosclerosis lesions and necrotic cores in Jak2V617F clonal hematopoiesis mice, despite improving fibrous cap thickness.
bioRxiv · Jun 3, 2025 · PreprintMolecular Biology