Author

David Ngai

Columbia University Irving Medical CenterORCID 0000-0002-9576-5254Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:transcription & RNA processing· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Alan R. TalliD· 2 shared Bernhard DorweileriD· 1 shared Brian D. HardawayiD· 1 shared Brian T HavensiD· 1 shared Cheng-Chieh HsuiD· 1 shared Eunyoung KimiD· 1 shared George Kuriakose· 1 shared Hanna WinteriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Alan R. TallORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution

David Ngai, Saheli Chowdhury, Santosh Reddy Sukka, George Kuriakose, Brian T Havens, Mustafa Yalçınkaya, Jeremy M. Frey, Heather Doviak, Jennifer W. Bradford, Bernhard Dorweiler, Hanna Winter, Lars Mäegdefessel, Kenneth Walsh, Joshua P. Thaler, Alan R. Tall, Ira A. Tabas

This study identifies IKKβ activation as a transient upstream signal triggered by efferocytosis that promotes tissue resolution through multiple downstream pathways.

Nature Communications · Oct 26, 2026Peer-reviewedImmunology

IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2V617F clonal hematopoiesis-driven atherosclerosis.

Mojdeh S. Tavallaie, Cheng-Chieh Hsu, Brian D. Hardaway, Huijuan Dou, Trevor P. Fidler, Eunyoung Kim, Sandra Abramowicz, David Ngai, Tong Xiao, Nan Wang, Marit Westerterp, Alan R. Tall

This study shows that IL-18 inhibition increases atherosclerosis lesions and necrotic cores in Jak2V617F clonal hematopoiesis mice, despite improving fibrous cap thickness.

bioRxiv · Jun 3, 2025 · PreprintMolecular Biology