Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
Om Prakash Dwivedi, Mikko Lehtovirta, Benoît Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie T. Richard, Fernando Abaitua, Nicola L. Beer, Antje K. Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, , Leif Groop
The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.
Nature Genetics · Nov 1, 2019Peer-reviewedGenetics