Author

Nicola L. Beer

University of OxfordORCID 0000-0002-4964-7150Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 4 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Benoît HastoyiD· 3 shared Anna L. GloyniD· 2 shared Anne Raimondo· 2 shared Emma AhlqvistiD· 2 shared Martijn van de BuntiD· 2 shared Patrik RorsmaniD· 2 shared Søren Krogsgaard ThomseniD· 2 shared A. Pitt· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenetics

Benoît HastoyORCID

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4 papers

Recent·Most cited

Machine Learning based histology phenotyping to investigate epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits

Craig A. Glastonbury, Sara L. Pulit, Julius Honecker, Jenny C. Censin, Samantha Laber, Hanieh Yaghootkar, Nilüfer Rahmioğlu, Emilie Pastel, Katarina Kos, A. Pitt, Michelle Hudson, Christoffer Nellåker, Nicola L. Beer, Hans Hauner, Christian Malte Becker, , Cecilia M. Lindgren

The paper develops a deep learning method for adipocyte phenotyping and finds adipocyte area correlates with BMI but no genome-wide significant genetic associations.

PLoS Computational Biology · Aug 14, 2020Peer-reviewedGenomics

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Om Prakash Dwivedi, Mikko Lehtovirta, Benoît Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie T. Richard, Fernando Abaitua, Nicola L. Beer, Antje K. Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, , Leif Groop

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

Nature Genetics · Nov 1, 2019Peer-reviewedGenetics

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

Natasha Hui Jin Ng, Sara M. Willems, Juan Fernandez, Rebecca S. Fine, Eleanor Wheeler, Jennifer Wessel, Hidetoshi Kitajima, Gaëlle Marenne, Jana K. Rundle, Xueling Sim, Hanieh Yeghootkar, Nicola L. Beer, Anne Raimondo, Andrei I. Tarasov, Soren K. Thomsen, , Abbas Dehghan

The paper identifies genetic variants and transcripts associated with glycemic traits by analyzing exome-array data from 144,600 individuals, highlighting tissue-specific roles in glucose regulation.

bioRxiv · Oct 3, 2019 · PreprintGenetics

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

Anne Raimondo, Søren Krogsgaard Thomsen, Benoît Hastoy, Mahesh Michael Umapathysivam, Xiao-Qing Dai, Jocelyn E. Manning Fox, Amy Barrett, Christopher J. Groves, Austin Bautista, Nicola L. Beer, Anne Clark, Patrick E. MacDonald, Patrik Rorsman, Anna L. Gloyn

This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.

bioRxiv · Jul 3, 2017 · PreprintGenetics