Hyperactive Rac1 drives MAPK-independent proliferation in melanoma by assembly of a mechanosensitive dendritic actin network
Ashwathi S. Mohan, Kevin M. Dean, Stacy Y. Kasitinon, Tadamoto Isogai, Vasanth Siruvallur Murali, Sangyoon J. Han, Philippe Roudot, Alex Groisman, Erik Welf, Gaudenz Danuser
This paper shows that a Rac1 mutation drives melanoma proliferation independently of MAPK signaling by forming a mechanosensitive actin network that inactivates the tumor suppressor NF2/Merlin.
bioRxiv · May 22, 2018 · PreprintCell Biology