A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin
Wei Gu, Xiaofeng Huang, Pratik Narendra Pratap Singh, Sanlan Li, Ying Lan, Min Deng, Lauretta A. Lacko, Jesús M. Gómez-Salinero, Shahin Rafii, Michael Paul Verzi, Ramesh A. Shivdasani, Qiao Zhou
The paper identifies MTA2 and SATB2 as a chromatin complex that maintains colonic identity by retaining HNF4A on colonic chromatin, preventing plasticity toward small intestine.
Nature Communications · Apr 27, 2024Peer-reviewedDevelopmental Biology