Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation
Swarnabh Bhattacharya, Guodong Tie, Pratik Narendra Pratap Singh…·Ramesh A. Shivdasani
The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.