Ramesh A. Shivdasani

The paper identifies and characterizes a novel intestinal epithelial cell type that co-expresses epithelial and lymphoid genes, distinct from known cell types.

This study identifies H3K27me3 as an epigenetic barrier that restricts intestinal stem cell transformation by maintaining enhancer repression and preventing fetal gene reactivation in colorectal cancer.

This study shows IL-22 promotes mucus-secreting cells in the small intestine, protecting mice from cholera by reducing V. cholerae colonization.

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

The paper shows Pdgfra+ fibroblasts reprogram during WNT-driven oncogenesis to promote a regenerative state in the epithelium, facilitating tumor formation.

This study identifies epigenetic changes and accelerated ageing in multifocal small intestinal neuroendocrine tumours, revealing altered metabolic gene regulation and tumour-specific methylation patterns.

This study investigates transcription factor dynamics during human enteroendocrine cell differentiation, finding that oscillations of ASCL1 and NEUROD1 enable accurate cell type diversification.

The paper identifies MTA2 and SATB2 as a chromatin complex that maintains colonic identity by retaining HNF4A on colonic chromatin, preventing plasticity toward small intestine.

The paper identifies transcriptional and epigenetic programs driving hair cell differentiation from supporting cells in cochlear organoids and predicts novel regulatory factors.

The paper identifies the adult mouse intestinal stem cell niche as a multi-layered structure with distinct mesenchymal and smooth muscle cell populations that regulate ISC proliferation and differentiation.

This study identifies Creb5 as a transcription factor required for TGF-β and EGFR signaling to induce Prg4 expression in superficial zone articular chondrocytes.

This study shows CDX2 has different chromatin-binding profiles in embryonic and adult intestines, leading to distinct gene activation patterns and developmental outcomes.

This paper discusses challenges and future directions in single-cell analysis, highlighting advances in technologies and computational methods for studying cellular heterogeneity.