Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Sara Alonso, Harsimran Kaur, Jia Luo, Mai-Uyen Nguyen, Alyssa M. Laguerta, Andrew Fong, Neema Skariah, Rafael José Argüello, Michael Paul Verzi, Mahima Swamy, Ken S. Lau, Karen L. Edelblum
This study shows that microbiota enhance CD39 expression in γδ IELs via TCR and IL-15 signaling, leading to regulatory IEL expansion and reduced inflammation.
Mucosal Immunology · Jul 17, 2025Peer-reviewedImmunology