Author

Alyssa M. Laguerta

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Andrew Fong· 1 shared Andy J. MinniD· 1 shared Anusha ThadiiD· 1 shared Chia‐Hui CheniD· 1 shared Christopher J. LengneriD· 1 shared Clara Morral· 1 shared Daana M. Roach· 1 shared Daniel Aleynick· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Andrew Fong

Author profile →

2 papers

Recent·Most cited

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn's disease

Tatiana A. Karakasheva, Clara Morral, Yusen Zhou, Jingya Qui, Xinyi E. Chen, Gloria E. Soto, Shaneice K. Nettleford, Olivia T. Hix, Daana M. Roach, Alyssa M. Laguerta, Anusha Thadi, Rachael M. Edwards, Daniel Aleynick, Sarah Weinbrom, Elizaveta Borodyanskaya, , Kathryn E. Hamilton

The paper identifies an inflammatory secretory progenitor cell state in Crohn's disease patients and shows its epigenetic regulation in stem cells.

Cellular and Molecular Gastroenterology and Hepatology · Oct 21, 2025Peer-reviewedPhysiology

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Sara Alonso, Harsimran Kaur, Jia Luo, Mai-Uyen Nguyen, Alyssa M. Laguerta, Andrew Fong, Neema Skariah, Rafael José Argüello, Michael Paul Verzi, Mahima Swamy, Ken S. Lau, Karen L. Edelblum

This study shows that microbiota enhance CD39 expression in γδ IELs via TCR and IL-15 signaling, leading to regulatory IEL expansion and reduced inflammation.

Mucosal Immunology · Jul 17, 2025Peer-reviewedImmunology