Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases
Nick Lee, Manmeet Bhalla, Joana M. Pereira, Stacie Clark, Sara E. Roggensack, Alenka Lovy, Michael J. Pereira, Guillermo Arroyo, Walter Adams, Andrew Camilli, Rodney K. Tweten, John M. Leong, Sandra Sousa, Elsa N. Bou Ghanem
This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.
bioRxiv · Apr 17, 2024 · PreprintMicrobiology