Author

Joana M. Pereira

Universidade do PortoORCID 0000-0001-9733-9665Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Sandra SousaiD· 2 shared Alenka LovyiD· 1 shared Ana X. Carvalho· 1 shared Andrew CamilliiD· 1 shared Cláudia BritoiD· 1 shared Daniel S. OsórioiD· 1 shared Didier CabanesiD· 1 shared Elsa N. Bou GhanemiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Sandra SousaORCID

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2 papers

Recent·Most cited

Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins

Cláudia Brito, Francisco Sarmento Mesquita, Joana M. Pereira, Daniel S. Osório, Neil Billington, Ricardo R. Lima, Sílvia Vale-Costa, James R. Sellers, Didier Cabanes, Ana X. Carvalho, Sandra Sousa

The paper identifies a protective pathway where LLO-induced Src activation phosphorylates NMHC2A, enabling cytoskeletal reorganization and PM damage response, conserved in C. elegans.

PLoS Pathogens · Feb 23, 2026Peer-reviewedMicrobiology

Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases

Nick Lee, Manmeet Bhalla, Joana M. Pereira, Stacie A. Clark, Sara E. Roggensack, Alenka Lovy, Michael J. Pereira, Guillermo Arroyo, Walter Adams, Andrew Camilli, Rodney K. Tweten, John M. Leong, Sandra Sousa, Elsa N. Bou Ghanem

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.

bioRxiv · Apr 17, 2024 · PreprintMicrobiology