Sandra Sousa

This study defines the structural mechanism of metal-induced DNA release by the ArsR/SmtB repressor CadC using crystal structures and biochemical analyses.

The paper identifies a protective pathway where LLO-induced Src activation phosphorylates NMHC2A, enabling cytoskeletal reorganization and PM damage response, conserved in C. elegans.

This study characterizes RmlT, a rhamnosyltransferase in L. monocytogenes, showing its role in WTA rhamnosylation and its potential as a target for antimicrobial strategies.

This study shows that pneumolysin from Streptococcus pneumoniae causes internalization of GPI-anchored proteins in lung epithelial cells via Rho GTPase activation, reducing cell death and membrane damage.