Author

Sara Isaac

Hebrew University of Jerusalem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:deconvolution· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Amir EdeniD· 3 shared Alaa DarwishiD· 2 shared Ahinoam Gugenheim· 1 shared Albert GrinshpuniD· 1 shared Anjeet Jhutty· 1 shared Antoni Bayés‐GenísiD· 1 shared Aviad ZickiD· 1 shared Aya Muharram· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersGenomics

Amir EdenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Improved deconvolution of circulating tumor DNA from ultra-low-pass whole-genome methylation sequencing using CelFiE-ISH

Efrat Katsman, Sara Isaac, Alaa Darwish, Myriam Maoz, Michal Inbar, MazalTov Marouani, Irene Unterman, Ahinoam Gugenheim, Nada Salaymeh, Shatha Abu Khdeir, Beatrice Uziely, Tamar Peretz, Luna Kaduri, Ayala Hubert, Jonathan E. Cohen, , Amir Eden

This study improves ctDNA deconvolution in ULP-WGS data using CelFiE-ISH, achieving lower cancer fraction detection limits than CNA benchmarks.

bioRxiv · Apr 18, 2026 · PreprintGenomics

Systematic errors in enzymatic conversion limit cell-free DNA methylation specificity

Netanel Loyfer, Judith Magenheim, Alaa Darwish, Sara Isaac, Jay Ganbat, Hussam Babikir, Anjeet Jhutty, Jonathan C. M. Wan, Antoni Bayés‐Genís, Elena Revuelta‐López, Amir Eden, Ravi Solanki, Yuval Dor, Tommy Kaplan

The paper identifies a systematic over-conversion error in EM-seq that introduces false-positive methylation signals in cfDNA analysis.

bioRxiv · Mar 26, 2026 · PreprintGenomics

A Novel Role for Nucleolin in Splice Site Selection

Kinneret Shefer, Ayub Boulos, Valer Gotea, Maram Arafat, Yair Ben-Chaim, Aya Muharram, Sara Isaac, Amir Eden, Joseph M. Sperling, Laura L. Elnitski, Ruth Sperling

This study identifies nucleolin as a novel regulator of splice site selection by directly interacting with initiator-tRNA, preventing latent splicing that would generate defective mRNAs.

RNA Biology · Feb 27, 2022Peer-reviewedGenomics