SUMOylation is a Therapeutic Vulnerability in High-risk Neuroblastoma
Antti Kukkula, Saiganesh Sriraman, Verneri Virtanen, Sara LM Kuusela, Lara Kozina Bubnic, Ilkka Paatero, Vilja M. Pietiäinen, Daniel Bexell, Maria Sundvall
This study identifies SUMOylation as a therapeutic target in high-risk neuroblastoma, showing that SUMO pathway inhibitors like TAK-981 reduce tumor growth and are effective in combination with other therapies.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology