17α-Estradiol Confers Limited Protection Against APOE4 Phenotypes in Middle-Aged Female Mice
Cassandra Joan McGill, Amy Christensen, Sara Namvari, Max Andrew Thorwald, Herbert Anson, Marc Vermulst, Caleb E. Finch, Bérénice Anath Benayoun, Christian J. Pike
This study tests if 17α-estradiol benefits APOE4 females similarly to males, finding limited CNS improvements but some metabolic benefits in APOE4 females.
bioRxiv · Aug 7, 2026 · PreprintSystems Biology