Protection against APOE4-associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male mice
Cassandra Joan McGill, Amy Christensen, Wenjie Qian, Max Andrew Thorwald, Jose Godoy Lugo, Sara Namvari, Olivia S. White, Caleb E. Finch, Bérénice Anath Benayoun, Christian J. Pike
This study shows that 17α-estradiol improves aging outcomes in APOE4 mice more than APOE3 mice, suggesting a genotype-dependent benefit of the intervention.
bioRxiv · Mar 12, 2024 · PreprintSystems Biology