Christian J. Pike

This study shows ApoE isoforms influence antioxidant pathways differently across aging, with ApoE4 showing stronger transcriptional responses but less effective protein production, linking to neurodegenerative risk.

This study tests if 17α-estradiol benefits APOE4 females similarly to males, finding limited CNS improvements but some metabolic benefits in APOE4 females.

This study shows that dietary protein restriction improves metabolic and cognitive health in aged female mice by altering the gut microbiome.

The paper investigates iron-mediated toxicity in Alzheimer's disease by analyzing postmortem brain tissue and ApoE4 mice, finding increased lipid peroxidation and decreased antioxidants in lipid rafts, which are reduced by iron chelation.

This study shows that 17α-estradiol improves aging outcomes in APOE4 mice more than APOE3 mice, suggesting a genotype-dependent benefit of the intervention.

This study shows that deleting TLR4 in microglia/macrophages reduces neuroinflammation and cognitive impairments in diet-induced obesity, with sex-specific effects.