Advancing Adoptive Cell Therapy: Optimized Expansion of Adaptive NK Cells for Solid Tumors
Nerea Martín Almazán, Sara Roman, Yizhe Sun, Lars Brautigam, Mattia Russel Pantalone, Giuseppe Stragliotto, Okan Gultekin, Sahar Saheli, Kaisa Lehti, Cecilia Söderberg Nauclér, Dhifaf Sarhan
This study shows that IL-21 enhances aNK cell expansion and cytotoxicity against tumors, with tumor lysate boosting their efficacy, validated in a zebrafish model.
bioRxiv · Oct 2, 2024 · PreprintImmunology