Author

Sarah A Howard

EpiCypher (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:CUT&Tag· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Anup VaidyaiD· 2 shared Bryan J. VentersiD· 2 shared Catherine A. MusselmaniD· 2 shared Eileen T. McAnarneyiD· 2 shared Ellen N WeinzapfeliD· 2 shared Hailey F. TayloriD· 2 shared Harrison A. FuchsiD· 2 shared Irina K PopovaiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Anup VaidyaORCID

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Author profile →

2 papers

Recent·Most cited

Nucleosome context regulates chromatin reader preference

Matthew R. Marunde, Irina K Popova, Nathan W Hall, Anup Vaidya, James R. Bone, Brandon A. Boone, Peter J. Brown, Ryan J. Ezell, Tessa M. Firestone, Harrison A. Fuchs, Elisa Gibson, Zachary B Gillespie, Susan L. Gloor, Allison R. Hickman, Sarah A Howard, , Jonathan M. Burg

The paper investigates how nucleosome context influences chromatin reader binding preferences using biochemical and genomic approaches, revealing that multivalent engagement often has regulatory effects beyond simple additivity.

Nucleic Acids Research · Oct 1, 2025Peer-reviewedBiochemistry

Nucleosome conformation dictates the histone code

Matthew R. Marunde, Harrison A. Fuchs, Jonathan M. Burg, Irina K Popova, Anup Vaidya, Nathan W Hall, Ellen N Weinzapfel, Matthew J. Meiners, Rachel Watson, Zachary B Gillespie, Hailey F. Taylor, Laylo Mukhsinova, Ugochi C. Onuoha, Sarah A Howard, Katherine Novitzky, , Catherine A. Musselman

The paper shows that histone reader domains interact with PTMs in a nucleosome-dependent manner, necessitating a refinement of the histone code concept to the nucleosome level.

eLife · Feb 6, 2024Peer-reviewedGenomics