Author

Ryan J. Ezell

EpiCypher (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:CUT&Tag· 1

Frequent Co-Authors

Alexander S. LeeiD· 2 shared Catherine A. MusselmaniD· 2 shared Hailey F. TayloriD· 2 shared Harrison A. FuchsiD· 2 shared Jonathan M. BurgiD· 2 shared Kelsey E. NolliD· 2 shared Laiba F. KhaniD· 2 shared Luis F. SchachneriD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Alexander S. LeeORCID

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Author profile →

2 papers

Recent·Most cited

Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry

Alexander S Lee, Nickolas P. Fisher, Matthew R. Marunde, Pei Su, Laiba F. Khan, Ryan J. Ezell, Zachary B Gillespie, Bria Graham, Hailey F. Taylor, Ugochi C. Onuoha, Taojunfeng Su, Kevin Jooß, Luis F. Schachner, Harrison A. Fuchs, Kelsey E. Noll, , Neil L. Kelleher

This paper introduces Nuc-MS, a method to directly analyze chromatin reader-nucleosome interactions by disassembling complexes and identifying histone proteoforms involved in binding.

ACS Central Science · Feb 5, 2026Peer-reviewedBiochemistry

Nucleosome context regulates chromatin reader preference

Matthew R. Marunde, Irina K Popova, Nathan W Hall, Anup Vaidya, James R. Bone, Brandon A. Boone, Peter J. Brown, Ryan J. Ezell, Tessa M. Firestone, Harrison A. Fuchs, Elisa Gibson, Zachary B Gillespie, Susan L. Gloor, Allison R. Hickman, Sarah A Howard, , Jonathan M. Burg

The paper investigates how nucleosome context influences chromatin reader binding preferences using biochemical and genomic approaches, revealing that multivalent engagement often has regulatory effects beyond simple additivity.

Nucleic Acids Research · Oct 1, 2025Peer-reviewedBiochemistry