Author

Sarah A Teichmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Ana CvejiciD· 2 shared Iain C Macaulay· 2 shared Adrian H Elcock· 1 shared Balazs Papp· 1 shared Balint Kintses· 1 shared Carol V Robinson· 1 shared Charlotte Labalette· 1 shared Csaba Pal· 1 shared

Activity by Year

2016-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

Ana CvejicORCID

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Author profile →

4 papers

Recent·Most cited

Genome-wide CRISPR screens in T helper cells reveal pervasive cross-talk between activation and differentiation

Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A Teichmann

The paper uses CRISPR screens in T helper cells to identify genes involved in Th2 differentiation and activation, revealing cross-talk between these processes.

bioRxiv · Dec 28, 2017 · PreprintImmunology

Single-cell transcriptome analysis of fish immune cells provides insight into the evolution of vertebrate immunity

Santiago J Carmona, Sarah A Teichmann, Lauren Ferreira, Iain C Macaulay, Michael J.T. Stubbington, Ana Cvejic, David Gfeller

The paper analyzes immune cell transcriptomes across vertebrates to reveal evolutionary patterns in gene conservation and turnover, finding higher gene turnover in NK cells compared to T cells.

Genome Research · Jan 13, 2017Peer-reviewedImmunology

Cotranslational assembly imposes evolutionary constraints on homomeric proteins

Eviatar Natan, Tamaki Endoh, Liora Haim-Vilmovsky, Guilhem Chalancon, Tilman Flock, Jonathan TS Hopper, Balint Kintses, Lejla Daruka, Gergely Fekete, Csaba Pal, Balazs Papp, Peter Horvath, Joseph A Marsh, Adrian H Elcock, M Madan Babu, , Sarah A Teichmann

The paper shows that homomeric proteins tend to have interfaces near the C-terminus, which is favorable for cotranslational assembly and reduces misassembly.

bioRxiv · Sep 13, 2016Cell Biology

Power Analysis of Single Cell RNA‐Sequencing Experiments

Valentine Svensson, Kedar N Natarajan, Lam-Ha Ly, Ricardo J Miragaia, Charlotte Labalette, Iain C Macaulay, Ana Cvejic, Sarah A Teichmann

This paper evaluates the sensitivity and accuracy of scRNA-seq protocols using spike-ins and a standardized pipeline, comparing sequencing depth trade-offs and RNA degradation effects.

bioRxiv · Sep 8, 2016Genomics