Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs
Christopher J. Winski, Peter V. Stuckey, Armando M. Marrufo, Georgina Agyei, Robbi L. Ross, Tamanna Urmi, Sarah Chapman, Felipe Hiram Santiago-Tirado
This study shows that the absence of PDR6 in Cryptococcus neoformans leads to a hyper-inflammatory immune response in mice, causing immune-dependent tissue damage and death rather than fungal burden.
mBio · May 30, 2025Peer-reviewedMicrobiology