Peter V. Stuckey

Set202 is a histone lysine methyltransferase that enables Cryptococcus neoformans to adapt to the host environment

This paper identifies Set202 as a histone methyltransferase in Cryptococcus neoformans that enables adaptation to host conditions by modifying gene expression through epigenetic mechanisms.

Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs

This study shows that the absence of PDR6 in Cryptococcus neoformans leads to a hyper-inflammatory immune response in mice, causing immune-dependent tissue damage and death rather than fungal burden.

The vacuolar protein 8 (Vac8) homolog in Cryptococcus neoformans plays conserved and unique roles in vacuolar and cellular morphology, impacting important stress responses and virulence traits

This study investigates the role of Vac8 in Cryptococcus neoformans, showing its impact on vacuolar morphology, stress responses, and virulence.

The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI

This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.