Felipe Hiram Santiago-Tirado

This paper identifies Set202 as a histone methyltransferase in Cryptococcus neoformans that enables adaptation to host conditions by modifying gene expression through epigenetic mechanisms.

This study identifies the Efg1 regulon active in C. albicans during growth in human urine, validates its clinical relevance in catheter samples, and characterizes key downstream factors involved in fungal CAUTI.

This study shows that liquid-infused silicone catheters reduce C. auris fungal burden, systemic spread, and inflammation in bladder infections.

This study identifies loss-of-function mutations in RBA1 as a convergent adaptation in C. auris that enhances its ability to adhere, form biofilms, and cause infections.

This study investigates how human microglia interact with Cryptococcus neoformans, showing limited phagocytic activity and ineffective killing of the fungus due to its ability to disrupt phagosome maturation.

This study shows that the absence of PDR6 in Cryptococcus neoformans leads to a hyper-inflammatory immune response in mice, causing immune-dependent tissue damage and death rather than fungal burden.

This study investigates the role of Vac8 in Cryptococcus neoformans, showing its impact on vacuolar morphology, stress responses, and virulence.

This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.