Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brain
Hans‐Ulrich Klein, Cristin Aubin, Elizabeta Gjoneska, Sarah E. Sullivan, Belinda J. Kaskow, Anna Y. Tang, Robert V. Smith, Jishu Xu, Andreas R. Pfenning, B Bernstein, Alexander Meissner, Julie A. Schneider, Sara Mostafavi, Li‐Huei Tsai, Tracy L. Young‐Pearse, , Philip L. De Jager
This study identifies tau pathology-driven chromatin organization changes in aged human brains and shows these effects can be reversed with HSP90 inhibitors.
Nature Neuroscience · Dec 12, 2018Peer-reviewedNeuroscience