Signalling pathways drive heterogeneity of ground state pluripotency
Kirsten R. McEwen, Sarah Linnett, Harry G. Leitch, Prashant Kumar Srivastava, Lara Al Zouabi, Tien-Chi Huang, Maxime Rotival, Alessandro Sardini, Thalia E. Chan, Sarah L. Filippi, Michael P. H. Stumpf, Enrico G. Petretto, Petra Hájková
This study shows that 2i conditions increase transcriptional heterogeneity in pluripotent stem cells, driven by signaling pathways and negative feedback loss.
bioRxiv · Aug 16, 2018 · PreprintMolecular Biology