Author

Tien-Chi Huang

MRC London Institute of Medical SciencesORCID 0000-0002-8464-166XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Petra HájkováiD· 2 shared Alessandro SardiniiD· 1 shared Camille DioniD· 1 shared Chad Whilding· 1 shared Enrico G. PetrettoiD· 1 shared Harry G. LeitchiD· 1 shared Irina Balaguer BalsellsiD· 1 shared Jingyu LiiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Petra HájkováORCID

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2 papers

Recent·Most cited

Global re-organisation of genome architecture at the transition to gametogenesis

Tien-Chi Huang, Maria Rigau, Valeriya Malysheva, Chad Whilding, Stella Siciliani, Jingyu Li, Irina Balaguer Balsells, Pavel Artemov, Camille Dion, Mikhail Spivakov, Juan M. Vaquerizas, Petra Hájková

This study reveals a unique 3D genome architecture in premeiotic gonadal germ cells, linked to epigenetic reprogramming and loss of TADs, alongside DNA demethylation.

Nature Structural & Molecular Biology · Feb 20, 2026Peer-reviewedCell Biology

Signalling pathways drive heterogeneity of ground state pluripotency

Kirsten R. McEwen, Sarah Linnett, Harry G. Leitch, Prashant Kumar Srivastava, Lara Al Zouabi, Tien-Chi Huang, Maxime Rotival, Alessandro Sardini, Thalia E. Chan, Sarah L. Filippi, Michael P. H. Stumpf, Enrico G. Petretto, Petra Hájková

This study shows that 2i conditions increase transcriptional heterogeneity in pluripotent stem cells, driven by signaling pathways and negative feedback loss.

bioRxiv · Aug 16, 2018 · PreprintMolecular Biology