Cell BiologybioRxivPreprint
TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism
Ryo Hagimori, Michael Landowski, Siyu Song…·Akihiro Ikeda
This study shows TMEM135 deficiency leads to a lipogenic state with increased monounsaturated fatty acids and DHA depletion, which is buffered by peroxisomal metabolism and can be reversed by fish oil.
DOI 10.64898/2026.07.22.740069