Richard S. Brush

This study shows that DHA deficiency causes lipid remodeling and microglial activation in mice, leading to oxidative stress and visual dysfunction, with APOE-dependent lipid disposal and galectin-3 involvement.

This study shows TMEM135 deficiency leads to a lipogenic state with increased monounsaturated fatty acids and DHA depletion, which is buffered by peroxisomal metabolism and can be reversed by fish oil.

This study shows that a Western diet in pregnant baboons alters the maternal microbiome and miRNA expression in placenta and fetal liver, potentially contributing to NAFLD and metabolic disease risk in offspring.