Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics
B. Vijayalakshmi Ayyar, Carmen V. Apostol, Janam J. Dave, Soni Kaundal, Joseph A. Kendra, Frederick H. Neill, Khalil Ettayebi, Sarah Maher, Ramakrishnan Anish, Gabriel Ignacio Parra, Göran Larson, Robert L. Atmar, Sue E. Crawford, B. V. Venkataram Prasad, Mary Kolb Estes
The paper compares GII.4 norovirus variants to determine if clustering and entry mechanisms are conserved, finding clustering enhances entry and is mediated by specific residues and lipid rafts.
Proceedings of the National Academy of Sciences · Oct 1, 2025Peer-reviewedMicrobiology