Janam J. Dave

This paper identifies critical molecular interactions of VP2 in HuNoV assembly through mutational analysis and computational modeling.

The paper compares GII.4 norovirus variants to determine if clustering and entry mechanisms are conserved, finding clustering enhances entry and is mediated by specific residues and lipid rafts.

This study shows that BTP2 inhibits Tulane virus and human norovirus replication by targeting structural proteins, not through SOCE, and establishes a system for antiviral screening.

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.