Author

B. Vijayalakshmi Ayyar

Baylor College of MedicineORCID 0000-0001-6775-9546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mary Kolb EstesiD· 4 shared Robert L. AtmariD· 4 shared Frederick H. NeilliD· 3 shared Sasirekha RamaniiD· 3 shared Sue E. CrawfordiD· 3 shared Janam J. DaveiD· 2 shared Ketki PatiliD· 2 shared Khalil EttayebiiD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

Mary Kolb EstesORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Functional Diversity in GII.4 Norovirus Entry: HBGA Binding and Capsid Clustering Dynamics

B. Vijayalakshmi Ayyar, Carmen V. Apostol, Janam J. Dave, Soni Kaundal, Joseph A. Kendra, Frederick H. Neill, Khalil Ettayebi, Sarah Maher, Ramakrishnan Anish, Gabriel Ignacio Parra, Göran Larson, Robert L. Atmar, Sue E. Crawford, B. V. Venkataram Prasad, Mary Kolb Estes

The paper compares GII.4 norovirus variants to determine if clustering and entry mechanisms are conserved, finding clustering enhances entry and is mediated by specific residues and lipid rafts.

Proceedings of the National Academy of Sciences · Oct 1, 2025Peer-reviewedMicrobiology

Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids

Gurpreet Kaur, Sue E. Crawford, Sasirekha Ramani, B. Vijayalakshmi Ayyar, Aaya Boussattach, Xi‐Lei Zeng, Robert L. Atmar, Hoa Nguyen‐Phuc, Cristian Coarfa, Mary Kolb Estes

This study identifies host restriction factors limiting HuNoV passaging in HIEs and demonstrates that TAK-779 enhances viral replication and enables continuous passaging.

bioRxiv · May 22, 2025 · PreprintMicrobiology

2'-Fucosyllactose Inhibits Human Norovirus Replication in Human Intestinal Enteroids

Ketki Patil, B. Vijayalakshmi Ayyar, Nicole M. Hayes, Frederick H. Neill, Lars Bode, Mary Kolb Estes, Robert L. Atmar, Sasirekha Ramani

This paper shows that 2'-fucosyllactose inhibits replication of a dominant human norovirus strain in intestinal enteroids from adult and pediatric donors.

Journal of Virology · Jan 10, 2025Peer-reviewedMicrobiology

Insights into Human Norovirus Cultivation in Human Intestinal Enteroids

Khalil Ettayebi, Gurpreet Kaur, Ketki Patil, Janam J. Dave, B. Vijayalakshmi Ayyar, Victoria R. Tenge, Frederick H. Neill, Xi‐Lei Zeng, Allison L. Speer, Sara C. Di Rienzi, Robert A. Britton, Sarah Elizabeth Blutt, Sue E. Crawford, Sasirekha Ramani, Robert L. Atmar, Mary Kolb Estes

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

mSphere · Oct 15, 2024Peer-reviewedMicrobiology