Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness
Onur Eskiocak, Saria Chowdhury, Vyom Shah, Emmanuella Nnuji-John, Charlie Chung, Jacob A. Boyer, Alexander S. Harris, Jill Habel, Michel Sadelain, Semir Beyaz, Corina Amor
This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.
bioRxiv · Mar 19, 2024 · PreprintCell Biology