Vyom Shah

This paper constructs a single-cell atlas of uterine carcinosarcoma across diverse ancestries, revealing cancer cell plasticity and stromal-immune remodeling in primary and metastatic tumors.

This paper develops an ancestrally inclusive patient-derived organoid platform for UCS that captures cancer cell plasticity and identifies therapeutic vulnerabilities.

The paper investigates how different high-fat diets affect host and microbiome multi-omic states over time and shows that some changes persist even after returning to a control diet.

This study shows CD8 T cells eliminate neoantigen+ epithelial stem cells in the colon, preventing cancer, without causing immunopathology.

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.