Onur Eskiocak

The paper identifies and characterizes a novel intestinal epithelial cell type that co-expresses epithelial and lymphoid genes, distinct from known cell types.

This paper constructs a single-cell atlas of uterine carcinosarcoma across diverse ancestries, revealing cancer cell plasticity and stromal-immune remodeling in primary and metastatic tumors.

This paper develops an ancestrally inclusive patient-derived organoid platform for UCS that captures cancer cell plasticity and identifies therapeutic vulnerabilities.

This study shows that a microbiome-dependent mechanism increases MHC-II expression in colon cancer cells, enhancing immunotherapy response and limiting metastasis.

This study characterizes the molecular differences in high-grade endometrial cancer across an ancestrally diverse cohort, identifying ancestry-associated mutations and immune microenvironment differences.

The paper investigates how different high-fat diets affect host and microbiome multi-omic states over time and shows that some changes persist even after returning to a control diet.

The paper shows that goblet and Paneth cells share similar gene expression and chromatin features, and their phenotypes are influenced by niche signals like BMP, suggesting a single cell type with plasticity.

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.