Dual regulation of the unfolded protein response by IGF2BP3 during ER stress
Aleksandra S. Anisimova, Sabina Omerbegovic, Milica Mihailović, Sascha Gratzl, Harald Hornegger, Irmgard Fischer, Gijs A. Versteeg, Stefan Ludwig Ameres, Gülsün Elif Karagöz
This study shows IGF2BP3 regulates UPR effectors by stabilizing transcriptional regulators and destabilizing UPR target mRNAs during ER stress, modulating the UPR response.
bioRxiv · Mar 29, 2025Cell Biology