Stefan Ludwig Ameres

The paper identifies MUT 15 as a pseudohelicase in the CPUG complex that remodels the nuclease module to regulate RNA cleavage and poly(UG)ylation.

This study investigates how uridylation mediates RNA decay in Drosophila by showing how Tailor generates oligo(U) intermediates and how Dis3l2 decodes these to initiate decay.

The paper identifies a homeostatic mechanism called interstasis that co-regulates the dosage of proteins with low complexity domains through RNA-based negative feedback.

The paper investigates the roles of Microprocessor and its cofactors ERH and SAFB1/2 in miRNA cluster assistance, revealing their distinct functional contributions to the process.

The paper identifies ERH and associated factors as post-transcriptional regulators of JAK2 mRNA maturation, essential for IFNγ signaling and innate immunity.

This study shows IGF2BP3 regulates UPR effectors by stabilizing transcriptional regulators and destabilizing UPR target mRNAs during ER stress, modulating the UPR response.

The paper investigates the assembly and functional resilience of the RNA exosome in mouse embryonic stem cells using CRISPR/Cas9, revealing a hierarchical assembly pathway and quality control mechanisms.

ORFtag enables proteome-scale tagging and functional screening in mammalian cells, identifying known and novel regulators of transcription and post-transcriptional processes.

The paper introduces mime-seq 2.0, a method to sequence microRNAs from specific mouse cell types using a chimeric RNA methyltransferase tethered to Argonaute.

This study uses SLAMseq to analyze maternal-to-zygotic transition in zebrafish, revealing early zygotic transcription and dynamics of maternal-zygotic gene expression.

The paper shows that small RNAs in mature mammalian sperm originate from epididymal somatic cells, not testicular germ cells, and are delivered via vesicular transport during post-testicular maturation.

SLAM-ITseq enables transcriptome analysis of specific cell types in tissues without prior sorting, providing accurate in vivo transcriptional snapshots.

SLAM-seq enables RNA polymerase II-dependent gene expression dynamics analysis by detecting 4-thiouridine incorporation at single-nucleotide resolution in mouse embryonic stem cells.