Author
University of ViennaORCID 0000-0002-6150-2165Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Irene Schwartz, Valentina Budroni, Mathilde Meyenberg…·Gijs A. Versteeg
The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.
Daniel B. Grabarczyk, Julian F. Ehrmann, Paul V. Murphy…·Tim Clausen
The paper presents the cryo-EM structure of the UBR4 complex, revealing its architecture and mechanism for substrate binding and ubiquitin chain extension in protein quality control.
Adrian Söderholm, Milica Vunjak, Melanie de Almeida…·Gijs A. Versteeg
The paper identifies ERH and associated factors as post-transcriptional regulators of JAK2 mRNA maturation, essential for IFNγ signaling and innate immunity.
Aleksandra S. Anisimova, Sabina Omerbegovic, Milica Mihailović…·Gülsün Elif Karagöz
This study shows IGF2BP3 regulates UPR effectors by stabilizing transcriptional regulators and destabilizing UPR target mRNAs during ER stress, modulating the UPR response.
Alexandra Shulkina, Kathrin Hacker, Julian F. Ehrmann…·Gijs A. Versteeg
The paper identifies TRIM52 as a primate-specific DNA repair factor under tight proteolytic control by BIRC6, HUWE1, and UBR4/KCMF1.
Annika Bestehorn, Jeanne Fesselet, Sebastian Didusch…·Pavel Kovarik
The paper shows that TTP regulates mRNA degradation by licensing its assembly on pre-mRNA, ensuring controlled inflammatory response termination.