Replication timing shapes the cancer epigenome and the nature of chromosomal rearrangements
Qian Du, Saul A. Bert, Nicola J. Armstrong, Catherine Elizabeth Caldon, Jenny Z. Song, Shalima S. Nair, Cathryn M. Gould, Phuc‐Loi Luu, Amanda Khoury, Wenjia Qu, Elena Zotenko, Clare Stirzaker, Susan J. Clark
This study shows that replication timing influences epigenetic changes and chromosomal rearrangements in cancer by linking early and late replication to specific methylation and histone modifications.
bioRxiv · Jan 22, 2018 · PreprintGenomics