Susan J. Clark

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

The paper examines DNA methylation dynamics in marsupial embryos, finding global demethylation in the trophectoderm but not the embryonic lineage, suggesting 5mC erasure in extraembryonic tissue is ancestral in therian mammals.

The paper uses isoform-specific single-cell Perturb-Seq to show that alternative promoters drive distinct transcriptional programs and affect drug response in breast cancer.

This study investigates how androgen stimulation reorganizes 3D genome and epigenome states in prostate cancer cells to activate AR-mediated transcription.

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.

This study shows that Decitabine suppresses tumour growth in ER+ breast cancer by inducing DNA hypomethylation and altering 3D chromatin structure.

This study shows DNA hypomethylation disrupts replication timing precision and 3D genome organisation in colorectal cancer DNMT1 and DNMT3B knockout cells.

The paper shows that chronic myeloid leukemia patients in molecular remission still have widespread aberrant alternative splicing, unlike normal gene expression and DNA methylation patterns.

This study shows BRG1 promotes proliferation in prostate cancer by regulating gene expression related to cell cycle and DNA replication, independent of AR and FOXA1.

The paper investigates the relationship between m5C modification in mRNA and translation by analyzing polysome profiles and validating m5C sites across different cell lines.

This study shows that replication timing influences epigenetic changes and chromosomal rearrangements in cancer by linking early and late replication to specific methylation and histone modifications.