Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice
Marilyn J. Duncan, Margaret R. Hawkins, Leke Bytyqi, Haleigh R Whitlock, Savannah M Shepard, MaKayla F. Cox, Esther G. Drinkard, Teresa Macheda, Kelly N. Roberts, Katharina Köhler, Mariella Schmidt, Carrie E. Johnson, Sridhar Sunderam, Bruce F. O’Hara, Michael Paul Murphy, Adam D. Bachstetter
This study shows that dim light at night disrupts circadian rhythms and increases amyloid pathology and microglial activation in a mouse model of Alzheimer's disease.
SLEEP · Feb 20, 2026Peer-reviewedNeuroscience