Adam D. Bachstetter

The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.

This study examines sex-specific mitochondrial changes in a mouse model of traumatic brain injury, revealing distinct spatial and temporal responses in mitochondrial function across brain regions.

This study shows that B cells modulate hippocampal neuronal activity after stroke, with effects dependent on age, sex, and injury status.

This study shows that dim light at night disrupts circadian rhythms and increases amyloid pathology and microglial activation in a mouse model of Alzheimer's disease.

This study shows that traumatic brain injury worsens mitochondrial dysfunction in APP/PS1 mice through time-dependent mechanisms, with sex differences in vulnerability.

This study examines the association between terminally differentiated effector memory T cells (TEMRAs) and cognitive and AD-related biomarkers in an aging cohort, finding CD8+ TEMRAs correlate with neuroinflammation markers.

This paper shows that probiotic treatment after spinal cord injury improves gut health and respiratory function by reducing inflammation and enhancing neuronal regeneration.

This study investigates the relationship between age and dystrophic microglia in the human brain, finding that dystrophic microglia are more prevalent in neurodegenerative diseases than in healthy aging.

This study validates and standardizes a radial-arm water maze protocol in mice to assess cognitive impairments after mild closed head traumatic brain injury.

This study investigates how aging affects astrocyte responses to traumatic brain injury in mice, finding age-related impairments in homeostatic functions and altered reactive astrogliosis.

The paper develops a computational model to simulate P2X-mediated calcium signaling in microglia and quantifies TNF production under various ATP stimulation conditions.