Bruce F. O’Hara

Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice

This study shows that dim light at night disrupts circadian rhythms and increases amyloid pathology and microglial activation in a mouse model of Alzheimer's disease.

Unbiased genetics identifies a glutamatergic signaling network as a mediator of daily sleep patterns.

The paper identifies a glutamatergic signaling network involving GRM5, GCPII, and GRM3 as a genetic mediator of daily sleep patterns through QTL mapping in mice.

Characterization of sleep in a mouse model of CLN3 disease revealed sex-specific sleep disturbances

The paper characterizes sleep disturbances in a mouse model of CLN3 disease, finding sex-specific differences in sleep patterns compared to wild-type controls.

Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1

This study shows that Iba1 deficiency in mice leads to microglial dysfunction, reduced synaptic development, and behavioral impairments.

Genetic Variation Regulates Opioid-Induced Respiratory Depression in Mice

The paper identifies genetic factors influencing opioid-induced respiratory depression in mice using genetic mapping and functional analysis.

Systems genetic discovery of host-microbiome interactions reveals mechanisms of microbial involvement in disease

The paper identifies host-microbiome interactions using systems genetics in mice, revealing mechanisms of microbial involvement in disease.

Noninvasive sleep monitoring in large-scale screening of knock-out mice reveals novel sleep-related genes

The paper identifies 122 novel sleep-related genes from a large-scale knockout mouse study using non-invasive sleep monitoring.

Rapid, noninvasive, and unsupervised detection of sleep/wake using piezoelectric monitoring for pharmacological studies in narcoleptic mice

This paper introduces PiezoSleep, a noninvasive method to detect sleep/wake in narcoleptic mice, showing it can identify phenotypes and screen drugs efficiently.