Author

Teresa Macheda

University of Kentucky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:metabolomics· 1

Frequent Co-Authors

Adam D. BachstetteriD· 4 shared Kelly N. Roberts· 4 shared Elika Z. MoallemiD· 2 shared Leke Bytyqi· 2 shared MaKayla F. CoxiD· 2 shared Margaret R. Hawkins· 2 shared Patrick G. SullivaniD· 2 shared Samir P. PateliD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersNeuroscience

Adam D. BachstetterORCID

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4 papers

Recent·Most cited

Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice

Elika Z. Moallem, Ronald C. Bruntz, MaKayla F. Cox, Leke Bytyqi, Taylor K Roberts, Samir P. Patel, Teresa Macheda, Kelly N. Roberts, Emma K. Higgins, Ramon C. Sun, Matthew S. Gentry, Patrick G. Sullivan, Lance A. Johnson, Adam D. Bachstetter

The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.

bioRxiv · Oct 6, 2026 · PreprintNeuroscience

Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice

Marilyn J. Duncan, Margaret R. Hawkins, Leke Bytyqi, Haleigh R Whitlock, Savannah M Shepard, MaKayla F. Cox, Esther G. Drinkard, Teresa Macheda, Kelly N. Roberts, Katharina Köhler, Mariella Schmidt, Carrie E. Johnson, Sridhar Sunderam, Bruce F. O’Hara, Michael Paul Murphy, Adam D. Bachstetter

This study shows that dim light at night disrupts circadian rhythms and increases amyloid pathology and microglial activation in a mouse model of Alzheimer's disease.

SLEEP · Feb 20, 2026Peer-reviewedNeuroscience

Traumatic brain injury exacerbates mitochondrial dysfunction in APP/PS1 knock-in mice through time-dependent pathways

Elika Z. Moallem, Hemendra J. Vekaria, Teresa Macheda, Margaret R. Hawkins, Kelly N. Roberts, Samir P. Patel, Patrick G. Sullivan, Adam D. Bachstetter

This study shows that traumatic brain injury worsens mitochondrial dysfunction in APP/PS1 mice through time-dependent mechanisms, with sex differences in vulnerability.

Experimental Neurology · Dec 30, 2025Peer-reviewedNeuroscience

Validation and standardization of a new radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury

Teresa Macheda, Kelly N. Roberts, Josh M. Morganti, David J. Braun, Adam D. Bachstetter

This study validates and standardizes a radial-arm water maze protocol in mice to assess cognitive impairments after mild closed head traumatic brain injury.

PLoS ONE · Aug 18, 2020Peer-reviewedNeuroscience