Author

Savitha Sridharan

University of California, Berkeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 4

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Hillel AdesnikiD· 4 shared Karthika GopakumariD· 2 shared Lamiae AbdeladimiD· 2 shared Mora Belén OgandoiD· 2 shared Stephen Graf BrohawniD· 2 shared Alexander NakaiD· 1 shared Andrew Egladyous· 1 shared Ben Shababo· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Hillel AdesnikORCID

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4 papers

Recent·Most cited

Feature-specific inhibitory connectivity augments the accuracy of cortical representations

Mora Belén Ogando, Lamiae Abdeladim, Kevin K. Sit, Hyeyoung Shin, Savitha Sridharan, Karthika Gopakumar, Hillel Adesnik

The paper shows that feature-specific inhibitory connectivity in cortical circuits enhances the accuracy of visual representations by enabling completion or cancelation of activity patterns.

bioRxiv · Aug 2, 2025 · PreprintNeuroscience

Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs

Kyle Tucker, Savitha Sridharan, Hillel Adesnik, Stephen Graf Brohawn

The paper presents cryo-EM structures of ChRmine, a microbial channelrhodopsin, in lipid nanodiscs, revealing its trimeric architecture and structural basis for its unique optogenetic properties.

Nature Communications · Aug 17, 2022Peer-reviewedNeuroscience

High performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks

Savitha Sridharan, Marta A. Gajowa, Mora Belén Ogando, Uday K. Jagadisan, Lamiae Abdeladim, Masato Sadahiro, Hayley A. Bounds, William D. Hendricks, Toby S. Turney, Ian Tayler, Karthika Gopakumar, Ian Antón Oldenburg, Stephen Graf Brohawn, Hillel Adesnik

This paper engineers high-performance microbial opsins for precise spatial and temporal control of neuronal networks, enabling large-scale activation of defined neurons in vivo and in vitro.

Neuron · Feb 3, 2022Peer-reviewedNeuroscience

Complementary networks of cortical somatostatin interneurons enforce layer specific control

Alexander Naka, Julia Veit, Ben Shababo, Rebecca K. Chance, Davide Risso, David A. Stafford, Benjamin J. Snyder, Andrew Egladyous, Desiree Chu, Savitha Sridharan, Daniel P. Mossing, Liam Paninski, John Ngai, Hillel Adesnik

The paper identifies distinct somatostatin interneuron circuits that specifically control activity in different cortical layers through complementary inhibitory mechanisms.

eLife · Mar 18, 2019Peer-reviewedNeuroscience