David A. Stafford

Neocortical long-range inhibition promotes cortical synchrony and sleep

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity

This study investigates neurogliaform cells in the visual cortex, showing their activity correlates with locomotion and their functional role is influenced by laminar position and connectivity.

Cortical somatostatin interneuron subtypes form cell-type specific circuits

The paper identifies cell-type specific circuits formed by subtypes of somatostatin interneurons in the cortex through genetic targeting and connectivity analysis.

Generation of a DAT-Flp mouse line for intersectional genetic targeting of dopamine neuron subpopulations

The paper introduces a DAT-Flp mouse line to selectively label dopaminergic subpopulations using intersectional genetic strategies.

Joint single cell DNA-Seq and RNA-Seq of gastric cancer reveals subclonal signatures of genomic instability and gene expression

The paper combines single cell DNA-Seq and RNA-Seq in gastric cancer to reveal subclonal genomic instability and gene expression patterns, showing evidence of tumor evolution.

Resolving the Full Spectrum of Human Genome Variation using Linked-Reads

This paper introduces Linked-Reads as a method to comprehensively analyze genome variation, showing it can detect both small and large variants and reconstruct haplotypes more effectively than short-read sequencing.

Complementary networks of cortical somatostatin interneurons enforce layer specific control

The paper identifies distinct somatostatin interneuron circuits that specifically control activity in different cortical layers through complementary inhibitory mechanisms.

Linked-Read sequencing resolves complex structural variants

This study evaluates Linked-Read sequencing for detecting structural variants, finding it can identify most known events with low sequencing depth and provides breakpoint resolution.