Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain
Jennifer Freire, Sicheng Pang, Joshua E. McGee, Maxwell J. Heinrich, Jiancheng Xie, Elijah Hammarlund, Dana C. Shaw, Yuxin Zhou, Yangyang Wang, Colin Porter, Lauren Dang, Erynne San Antonio, Ziqing Yu, K. Li, Scellig Stone, , Xue Han
This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.
bioRxiv · Oct 30, 2025 · PreprintNeuroscience